Abstract
A series of N-substituted glycine oligomers (peptoids) and peptide-peptoid hybrids were synthesized based on the Ac-His-Phe-Arg-Trp-NH(2) tetrapeptide template. The compounds were pharmacologically characterized at the mouse melanocortin receptors (MC1R, MC3R-MC5R) for agonist activity.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Amino Acid Sequence
-
Animals
-
Cell Line
-
Drug Design
-
Glycine / analogs & derivatives
-
Humans
-
Kinetics
-
Ligands
-
Mice
-
Models, Molecular
-
Oligopeptides / chemistry
-
Peptides / chemical synthesis*
-
Peptides / chemistry
-
Peptides / pharmacology*
-
Peptoids / chemical synthesis*
-
Peptoids / chemistry
-
Peptoids / pharmacology*
-
Receptor, Melanocortin, Type 3 / agonists*
-
Receptor, Melanocortin, Type 3 / chemistry
-
Receptor, Melanocortin, Type 3 / drug effects
-
Receptor, Melanocortin, Type 4 / agonists*
-
Receptor, Melanocortin, Type 4 / chemistry
-
Receptor, Melanocortin, Type 4 / drug effects
-
Recombinant Proteins / agonists
-
Recombinant Proteins / chemistry
-
Recombinant Proteins / drug effects
-
Structure-Activity Relationship
-
Transfection
Substances
-
Ligands
-
Oligopeptides
-
Peptides
-
Peptoids
-
Receptor, Melanocortin, Type 3
-
Receptor, Melanocortin, Type 4
-
Recombinant Proteins
-
Glycine